Carbon fibre composites: Integrated electrochemical sensors for wound management

被引：15

作者：

Sharp, Duncan ^{[1
]}

Forsythe, Stephen ^{[1
]}

Davis, James ^{[1
]}

机构：

[1] Nottingham Trent Univ, Sch Sci & Technol, Nottingham NG11 8NS, England

来源：

JOURNAL OF BIOCHEMISTRY | 2008年 / 144卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

carbon fibre; smart bandage; urate; uric acid; wound infection;

D O I：

10.1093/jb/mvn045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The applicability of employing a carbon fibre mesh as an electrochemical sensing substructure for assessing urate transformations within wound exudates is evaluated. Prototype sensor assemblies have been designed and their response characteristics towards uric acid and other common physiological components are detailed. Modification of the carbon fibre sensor through surface anodization and the application of cellulose acetate permselective barriers have been shown to lead to optimized responses and much greater sensitivity (1440% increase) and specificity. These could enable the accurate periodic monitoring of uric acid in wound fluid. The performance characteristics of the composite sensors in whole blood, serum and blister fluid have been investigated.

引用

页码：87 / 93

页数：7

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