Concise Review: LIN28/let-7 Signaling, a Critical Double-Negative Feedback Loop During Pluripotency, Reprogramming, and Tumorigenicity

被引：50

作者：

Farzaneh, Maryam ^{[1
]}

Attari, Farnoosh ^{[2
]}

Khoshnam, Seyed Esmaeil ^{[3
,4
]}

机构：

[1] ACECR, Royan Inst Stem Cell Biol & Technol, Dept Stem Cells & Dev Biol, Cell Sci Res Ctr, Tehran 1665666311, Iran

[2] Univ Tehran, Sch Biol, Dept Anim Biol, Coll Sci, Tehran, Iran

[3] Ahvaz Jundishapur Univ Med Sci, Dept Physiol, Physiol Res Ctr, Fac Med, Ahvaz, Iran

[4] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran

来源：

CELLULAR REPROGRAMMING | 2017年 / 19卷 / 05期

关键词：

miRNAs; LIN28/let-7; pluripotent stem cells; cancer stem cells; reprogramming; tumorigenicity; CELL SELF-RENEWAL; LET-7; MICRORNAS; STEM-CELLS; LIN28; EXPRESSION; BIOGENESIS; MECHANISM; MIRNAS; FAMILY; LIN-28;

D O I：

10.1089/cell.2017.0015

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

MicroRNAs (miRNAs) with 20-30 nucleotides have recently emerged as the multidimensional regulators of cell fate decisions. Recent improvement in high-throughput sequencing has highlighted the potential role of LIN28/let-7 regulatory network in several developmental events. It was proposed that this pathway might represent a functional signature in cell proliferation, transition between commitment and pluripotency, and regulation of cancer and tumorigenicity. LIN28/let-7 regulatory pathway is one of the excellent examples of the relationship between an miRNA and mRNAs. This review article highlights the potentials of LIN28/let-7 signaling in gene regulatory pathways during pluripotency, reprogramming, and tumorigenicity.

引用

页码：289 / 293

页数：5

共 51 条

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