In situ detection of single micron-sized magnetic beads using magnetic tunnel junction sensors

被引：90

作者：

Shen, WF ^{[1
]}

Liu, XY

Mazumdar, D

Xiao, G

机构：

[1] Brown Univ, Dept Phys, Providence, RI 02912 USA

[2] Micro Magnet Inc, Fall River, MA 02720 USA

来源：

APPLIED PHYSICS LETTERS | 2005年 / 86卷 / 25期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.1952582

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We have demonstrated the use of highly sensitive magnetic tunnel junction (MTJ) sensors for the detection of individual micron-sized magnetic labels. By integrating the MTJ sensor into a microfluidic channel, we were able to detect the presence of moving superparamagnetic beads (Dynabeads (R) M-280) in real time by direct measurement of the magnetic dipole fields associated with single beads. The dipolar fields of a single bead were sufficient to obtain a signal of 80 m V with signal to noise ratio of 24 dB in an applied field of 15 Oe. Our data show conclusively that MTJ sensors are very promising candidates for future applications involving the accurate detection and identification of biomolecules with magnetic labels. (c) 2005 American Institute of Physics.

引用

收藏

页码：1 / 3

页数：3

相关论文

共 16 条

[1] A biosensor based on magnetoresistance technology [J].

Baselt, DR ;

Lee, GU ;

Natesan, M ;

Metzger, SW ;

Sheehan, PE ;

Colton, RJ .

BIOSENSORS & BIOELECTRONICS, 1998, 13 (7-8) :731-739

[2] Prototyping of masks, masters, and stamps/molds for soft lithography using an office printer and photographic reduction [J].

Deng, T ;

Wu, HK ;

Brittain, ST ;

Whitesides, GM .

ANALYTICAL CHEMISTRY, 2000, 72 (14) :3176-3180

[3] Rapid prototyping of microfluidic systems in poly(dimethylsiloxane) [J].

Duffy, DC ;

McDonald, JC ;

Schueller, OJA ;

Whitesides, GM .

ANALYTICAL CHEMISTRY, 1998, 70 (23) :4974-4984

[4] Magnetoresistive-based biosensors and biochips [J].

Graham, DL ;

Ferreira, HA ;

Freitas, PP .

TRENDS IN BIOTECHNOLOGY, 2004, 22 (09) :455-462

[5] Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: Biotechnological applications [J].

Graham, DL ;

Ferreira, H ;

Bernardo, J ;

Freitas, PP ;

Cabral, JMS .

JOURNAL OF APPLIED PHYSICS, 2002, 91 (10) :7786-7788

[6] Advancements toward magneto immunoassays [J].

Kriz, K ;

Gehrke, J ;

Kriz, D .

BIOSENSORS & BIOELECTRONICS, 1998, 13 (7-8) :817-823

[7] Field sensing using the magnetoresistance of IrMn exchange-biased tunnel junctions [J].

Lacour, D ;

Jaffrès, H ;

Van Dau, FN ;

Petroff, F ;

Vaurès, A ;

Humbert, J .

JOURNAL OF APPLIED PHYSICS, 2002, 91 (07) :4655-4658

[8] Detection of single micron-sized magnetic bead and magnetic nanoparticles using spin valve sensors for biological applications [J].

Li, GX ;

Joshi, V ;

White, RL ;

Wang, SX ;

Kemp, JT ;

Webb, C ;

Davis, RW ;

Sun, SH .

JOURNAL OF APPLIED PHYSICS, 2003, 93 (10) :7557-7559

[9] Magnetic tunneling junctions with permalloy electrodes: a study of barrier, thermal annealing, and interlayer coupling [J].

Liu, XY ;

Ren, C ;

Ritchie, L ;

Schrag, BD ;

Xiao, G ;

Li, LF .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2003, 267 (01) :133-138

[10] Magnetic tunnel junction field sensors with hard-axis bias field [J].

Liu, XY ;

Ren, C ;

Xiao, G .

JOURNAL OF APPLIED PHYSICS, 2002, 92 (08) :4722-4725