Dendritic spine plasticity: Looking beyond development

被引:55
作者
Harms, Kimberly J. [1 ]
Dunaeusky, Anna [1 ]
机构
[1] Brown Univ, Dept Neurosci, Providence, RI 02912 USA
关键词
dendritic spines; synapse; plasticity;
D O I
10.1016/j.brainres.2006.02.094
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Most excitatory synapses in the CNS form on dendritic spines, tiny protrusions from the dendrites of excitatory neurons. As such, spines are likely loci of synaptic plasticity. Spines are dynamic structures, but the functional consequences of dynamic changes in these structures in the mature brain are unclear. Changes in spine density, morphology, and motility have been shown to occur with paradigms that induce synaptic plasticity, as well as altered sensory experience and neuronal activity. These changes potentially lead to an alteration in synaptic connectivity and strength between neuronal partners, affecting the efficacy of synaptic communication. Here, we review the formation and modification of excitatory synapses on dendritic spines as it relates to plasticity in the central nervous system after the initial phase of synaptogenesis. We will also discuss some of the molecular links that have been implicated in both synaptic plasticity and the regulation of spine morphology. (C) 2006 Published by Elsevier B.V.
引用
收藏
页码:65 / 71
页数:7
相关论文
共 95 条
[51]   Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity [J].
Maletic-Savatic, M ;
Malinow, R ;
Svoboda, K .
SCIENCE, 1999, 283 (5409) :1923-1927
[52]   AMPA receptor trafficking and synaptic plasticity [J].
Malinow, R ;
Malenka, RC .
ANNUAL REVIEW OF NEUROSCIENCE, 2002, 25 :103-126
[53]   Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons [J].
Matsuzaki, M ;
Ellis-Davies, GCR ;
Nemoto, T ;
Miyashita, Y ;
Iino, M ;
Kasai, H .
NATURE NEUROSCIENCE, 2001, 4 (11) :1086-1092
[54]   Structural basis of long-term potentiation in single dendritic spines [J].
Matsuzaki, M ;
Honkura, N ;
Ellis-Davies, GCR ;
Kasai, H .
NATURE, 2004, 429 (6993) :761-766
[55]   Fear conditioning induces a lasting potentiation of synaptic currents in vitro [J].
McKernan, MG ;
ShinnickGallagher, P .
NATURE, 1997, 390 (6660) :607-611
[56]   Miniature synaptic events maintain dendritic spines via AMPA receptor activation [J].
McKinney, RA ;
Capogna, M ;
Dürr, R ;
Gähwiler, BH ;
Thompson, SM .
NATURE NEUROSCIENCE, 1999, 2 (01) :44-49
[57]   In and out of the postsynaptic region: signalling proteins on the move [J].
Meyer, T ;
Shen, K .
TRENDS IN CELL BIOLOGY, 2000, 10 (06) :238-244
[58]   SYNAPTIC POTENTIATION IN THE RAT DENTATE GYRUS DURING EXPLORATORY LEARNING [J].
MOSER, E ;
MOSER, MB ;
ANDERSEN, P .
NEUROREPORT, 1993, 5 (03) :317-320
[59]  
Moser MB, 1997, J COMP NEUROL, V380, P373, DOI 10.1002/(SICI)1096-9861(19970414)380:3<373::AID-CNE6>3.0.CO
[60]  
2-#