Rhodium-catalyzed chemo-, regio-, and enantioselective [2+2+2] cycloaddition of alkynes with isocyanates

被引：121

作者：

Tanaka, K ^{[1
]}

Wada, A

Noguchi, K

机构：

[1] Tokyo Univ Agr & Technol, Dept Appl Chem, Grad Sch Engn, Koganei, Tokyo 1848588, Japan

[2] Tokyo Univ Agr & Technol, Instrumentat Anal Ctr, Koganei, Tokyo 1848588, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 21期

关键词：

D O I：

10.1021/ol052041b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a cationic rhodium([)/modified-BINAP complex-catalyzed chemoselective [2 + 2 + 2] cycloaddition of alkynes with isocyanates leading to a wide range of 2-pyridones. This method was successfully applied to the chemo-, regio-, and enantioselective synthesis of axially chiral 2-pyridones from unsymmetrical alpha,omega,-diynes, bearing an ortho-substituted phenyl at one terminal position, and alkyl isocyanates.

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页码：4737 / 4739

页数：3

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