Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus

被引：110

作者：

Olszewski, PK

Li, DH

Grace, MK

Billington, CJ

Kotz, CM

Levine, AS

机构：

[1] Vet Affairs Med Ctr, Res Serv 151, Minneapolis, MN 55417 USA

[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Food Sci & Nutr, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Coll Vet Med, Minneapolis, MN 55455 USA

来源：

PEPTIDES | 2003年 / 24卷 / 04期

关键词：

ghrelin; food intake; paraventricular nucleus of the hypothalamus; lateral hypothalamus; arcuate nucleus; nucleus of the solitary tract; dorsomedial nucleus of the hypothalamus; central nucleus of the amygdala; orexin; hypocretin; Fos; immunohistochemistry;

D O I：

10.1016/S0196-9781(03)00105-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin stimulates feeding when administered centrally and peripherally. The lateral hypothalamus (LH) is thought to mediate ghrelin-induced hyperphagia. Thus, we examined central mechanisms underlying feeding generated by LH ghrelin. We determined that 0.3 nmol of LH-injected ghrelin was the lowest dose increasing food consumption and it induced Fos immunoreactivity (IR; a marker of neuronal activation) in feeding-related brain areas, including the hypothalamic paraventricular, arcuate, and dorsomedial nuclei, amygdala, and nucleus of the solitary tract. Also, LH ghrelin induced Fos IR in LH orexin neurons. We conclude that the LH, as part of larger central circuitry, integrates orexigenic properties of ghrelin. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：597 / 602

页数：6

共 33 条

[31] Ghrelin causes hyperphagia and obesity in rats [J].