Development and validation of liquid chromatography and capillary electrophoresis methods for acarbose determination in pharmaceutical tablets

被引：11

作者：

Cherkaoui, S ^{[1
]}

Daali, Y ^{[1
]}

Christen, P ^{[1
]}

Veuthey, JL ^{[1
]}

机构：

[1] Univ Geneva, Lab Pharmaceut Analyt Chem, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 18卷 / 4-5期

关键词：

acarbose; liquid chromatography; capillary electrophoresis; evaporative light scattering detector; validation;

D O I：

10.1016/S0731-7085(98)00216-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Liquid chromatography and capillary zone electrophoresis, respectively coupled to an evaporative light scattering detector and a UV detector have been developed for the analysis of acarbose without any derivatization procedure. The electrophoretic separation of acarbose anomers was achieved through the manipulation of the working temperature. Both methods were validated and showed good validation data in terms of precision, accuracy and linearity. The validated methods were successfully applied to the dosage of acarbose in commercially available Glucobay(R) tablets. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：729 / 735

页数：7

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