Cytokine regulation by virus infection: Bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro

被引：37

作者：

Adler, H ^{[1
]}

Jungi, TW ^{[1
]}

Pfister, H ^{[1
]}

Strasser, M ^{[1
]}

Sileghem, M ^{[1
]}

Peterhans, E ^{[1
]}

机构：

[1] UNIV BERN,INST VET VIROL,CH-3012 BERN,SWITZERLAND

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 04期

关键词：

D O I：

10.1128/JVI.70.4.2650-2653.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bovine bone marrow-derived mascrophages were infected in vitro with noncytopathic or cytopathic strains of bovine viral diarrhea virus. Infection with both biotypes resulted in a decreased production of tumor necrosis factor alpha upon stimulation with heat-inactivated Salmonella dublin or lipopolysaccharide. Other macrophage functions were not downregulated,indicating that the observed effect was not due to a loss in macrophage viability. The downregulated production of tumor necrosis factor alpha in infected macrophages may contribute to the well-documented immunosuppression in animals infected with bovine viral diarrhea virus.

引用

页码：2650 / 2653

页数：4

共 31 条

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