Relation between use of anti hypertensive medications and risk of breast carcinoma among women ages 65-79 years

被引:115
作者
Li, CI
Malone, KE
Weiss, NS
Boudreau, DM
Cushing-Haugen, KL
Daling, JR
机构
[1] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Publ Hlth Sci Div, Seattle, WA 98109 USA
[2] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[3] Ctr Hlth Studies, Grp Hlth Cooperat, Seattle, WA USA
关键词
breast neoplasms; calcium channel blockers; adrenergic beta-antagonists; angiotensin-converting enzyme inhibitors; diuretics;
D O I
10.1002/cncr.11663
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. Limited data are available regarding the incidence of breast carcinoma among users of relatively recently introduced forms of antihypertensive therapy. Although it has been suggested that women who have taken calcium channel blockers (CCBs) have an increased risk and that women who have taken angiotensin-I-converting enzyme (ACE) inhibitors have a decreased risk, currently, no conclusions can be drawn. METHODS. A population-based case-control study of women ages 65-79 years was conducted in western Washington State. The responses of 975 women who were diagnosed with invasive breast carcinoma during 1997-1999 were compared with the responses of 1007 women in a control group. Associations between use of different types of antihypertensive medications and breast carcinoma incidence were evaluated using logistic regression. RESULTS. Overall, women who had ever used CCBs, beta-blockers, or ACE inhibitors did not have an altered risk of breast carcinoma relative to women who had never used antihypertensive medications. Although the use of immediate- release CCBs, thiazide diuretics, and potassium-sparing diuretics was associated with modestly increased risks of breast carcinoma (odds ratio [OR], 1.5; 95% confidence interval [95% CI] 1.0-2.1; OR, 1.4; 95% CI, 1.1-1.8; and OR, 1.6; 95% CI, 1.2-2.1, respectively), the absence of any trend in the size of excess risk with increasing duration or with current versus former use of these agents argues for a cautious interpretation. CONCLUSIONS. The use of particular types of antihypertensive medications, including immediate-release CCBs and certain diuretics, may increase the risk of breast carcinoma among older women. Additional studies are warranted to clarify these potential associations. Cancer 2003;98:1504-13. (C) 2003 American Cancer Society.
引用
收藏
页码:1504 / 1513
页数:10
相关论文
共 33 条
[11]  
Furberg CD, 2002, JAMA-J AM MED ASSOC, V288, P2981
[12]   Circulating concentrations of insulin-like growth factor-I and risk of breast cancer [J].
Hankinson, SE ;
Willett, WC ;
Colditz, GA ;
Hunter, DJ ;
Michaud, DS ;
Deroo, B ;
Rosner, B ;
Speizer, FE ;
Pollak, M .
LANCET, 1998, 351 (9113) :1393-1396
[13]   Cancer risk of hypertensive patients taking calcium antagonists [J].
Hole, DJ ;
Gillis, CR ;
McCallum, IR ;
McInnes, GT ;
MacKinnon, PL ;
Meredith, PA ;
Murray, LS ;
Robertson, JWK ;
Lever, AF .
JOURNAL OF HYPERTENSION, 1998, 16 (01) :119-124
[14]   Calcium-channel blockers and risk of cancer [J].
Jick, H ;
Jick, S ;
Derby, LE ;
Vasilakis, C ;
Myers, MW ;
Meier, CR .
LANCET, 1997, 349 (9051) :525-528
[15]   INCREASED ACTIVITY OF L-TYPE CA2+ CHANNELS EXPOSED TO SERUM FROM PATIENTS WITH TYPE-I DIABETES [J].
JUNTTIBERGGREN, L ;
LARSSON, O ;
RORSMAN, P ;
AMMALA, C ;
BOKVIST, K ;
WAHLANDER, K ;
NICOTERA, P ;
DYPBUKT, J ;
ORRENIUS, S ;
HALLBERG, A ;
BERGGREN, PO .
SCIENCE, 1993, 261 (5117) :86-90
[16]   COMPARING SELF-REPORTED AND PHYSICIAN-REPORTED MEDICAL HISTORY [J].
KEHOE, R ;
WU, SY ;
LESKE, MC ;
CHYLACK, LT .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1994, 139 (08) :813-818
[17]   Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? [J].
Lever, AF ;
Hole, DJ ;
Gillis, CR ;
McCallum, IR ;
McInnes, GT ;
MacKinnon, PL ;
Meredith, PA ;
Murray, LS ;
Reid, JL ;
Robertson, JWK .
LANCET, 1998, 352 (9123) :179-184
[18]   Angiotensin-converting enzyme inhibitors, calcium channel blockers, and breast cancer [J].
Meier, CR ;
Derby, LE ;
Jick, SS ;
Jick, H .
ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (03) :349-353
[19]  
Michels KB, 1998, CANCER, V83, P2003, DOI 10.1002/(SICI)1097-0142(19981101)83:9<2003::AID-CNCR17>3.3.CO
[20]  
2-V