Light and melatonin inhibit in vivo serotonergic phase advances without altering serotonergic-induced decrease of per expression in the hamster suprachiasmatic nucleus

被引:13
作者
Caldelas, I [1 ]
Challet, E [1 ]
Saboureau, M [1 ]
Pevet, P [1 ]
机构
[1] Univ Louis Pasteur Strasbourg 1, Lab Neurobiol Rhythms, CNRS, UMR7518,Dept Neurosci,IFR37, Strasbourg, France
关键词
circadian rhythm; 8-OH-DPAT; nonphotic cues; locomotor activity; clock gene;
D O I
10.1385/JMN:25:1:053
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the Syrian hamster a serotonergic (5-HTergic) stimulation during daytime acts on the circadian timing system by inducing behavioral phase advances and by decreasing Per1 and Per2 (Period) mRNA levels in the suprachiasmatic nuclei, containing the main circadian clock in mammals. The present study was conducted in Syrian hamsters, housed in constant darkness, to investigate the interactions between light or melatonin with serotonergic Stimulation in terms of phase resetting and clock gene expression. Both light exposure and systemic administration of melatonin prior to the injection of a 5-HT1A/7 receptor agonist, 8-OH-DPAT, in the middle of the day blocked behavioral phase advances. In contrast, neither light nor melatonin treatment during daytime prevented serotonergic-induced down-regulation of Per1 and/or Per2 mRNA levels in the suprachiasmatic nuclei. Taken to-ether, the results show that interactions between afferent cues to the suprachiasmatic nuclei differentially modulate phase adjustment and clock gene expression during daytime.
引用
收藏
页码:53 / 63
页数:11
相关论文
共 67 条
[1]   Activity-induced circadian clock resetting in the Syrian hamster: effects of melatonin [J].
Antle, MC ;
Ludgate, S ;
Mistlberger, RE .
NEUROSCIENCE LETTERS, 2002, 317 (01) :5-8
[2]   Circadian tryptophan hydroxylase levels and serotonin release in the suprachiasmatic nucleus of the rat [J].
Barassin, S ;
Raison, S ;
Saboureau, M ;
Bienvenu, C ;
Maître, M ;
Malan, A ;
Pévet, P .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 15 (05) :833-840
[3]   Interactions between light and melatonin on the circadian clock of mice [J].
Benloucif, S ;
Masana, MI ;
Yun, K ;
Dubocovich, ML .
JOURNAL OF BIOLOGICAL RHYTHMS, 1999, 14 (04) :281-289
[4]   Serotonergic stimulation and nonphotic phase-shifting in hamsters [J].
Bobrzynska, KJ ;
Godfrey, MH ;
Mrosovsky, N .
PHYSIOLOGY & BEHAVIOR, 1996, 59 (02) :221-230
[5]   Circadian profile and photic regulation of clock genes in the suprachiasmatic nucleus of a diurnal mammal Arvicanthis ansorgei [J].
Caldelas, I ;
Poirel, VJ ;
Sicard, B ;
Pévet, P ;
Challet, E .
NEUROSCIENCE, 2003, 116 (02) :583-591
[6]   Interactions between photic and nonphotic stimuli to synchronize the master circadian clock in mammals [J].
Challet, E ;
Pévet, P .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2003, 8 :S246-S257
[7]   Light exposure during daytime modulates expression of Per1 and Per2 clock genes in the suprachiasmatic nuclei of mice [J].
Challet, E ;
Poirel, VJ ;
Malan, A ;
Pévet, P .
JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 72 (05) :629-637
[8]   Roles of suprachiasmatic nuclei and intergeniculate leaflets in mediating the phase-shifting effects of a serotonergic agonist and their photic modulation during subjective day [J].
Challet, E ;
Scarbrough, K ;
Penev, PD ;
Turek, FW .
JOURNAL OF BIOLOGICAL RHYTHMS, 1998, 13 (05) :410-421
[9]   Phase-shifting effect of 8-OH-DPAT, a 5-HT1A/5-HT7 receptor agonist, on locomotor activity in golden hamster in constant darkness [J].
Cutrera, RA ;
Saboureau, M ;
Pevet, P .
NEUROSCIENCE LETTERS, 1996, 210 (01) :1-4
[10]   SPECIFIC DESTRUCTION OF THE SEROTONERGIC AFFERENTS TO THE SUPRACHIASMATIC NUCLEI PREVENTS TRIAZOLAM-INDUCED PHASE ADVANCES OF HAMSTER ACTIVITY RHYTHMS [J].
CUTRERA, RA ;
KALSBEEK, A ;
PEVET, P .
BEHAVIOURAL BRAIN RESEARCH, 1994, 62 (01) :21-28