Enabling the chemistry of life

被引：91

作者：

Walsh, C ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NATURE | 2001年 / 409卷 / 6817期

关键词：

D O I：

10.1038/35051697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in product-determining reactions. Many enzymes are members of families that carry out related chemical transformations and offer opportunities for directed in vitro evolution, to tailor catalytic properties to particular functions.

引用

页码：226 / 231

页数：6

共 30 条

[1]

[Anonymous], 1999, RNA WORLD

[2]

Atkins J. F., 1999, RNA WORLD

[3] The enolase superfamily: A general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids [J].

Babbitt, PC ;

Hasson, MS ;

Wedekind, JE ;

Palmer, DRJ ;

Barrett, WC ;

Reed, GH ;

Rayment, I ;

Ringe, D ;

Kenyon, GL ;

Gerlt, JA .

BIOCHEMISTRY, 1996, 35 (51) :16489-16501

[4]

BERTINO I, 1994, BIOINORGANIC CHEM

[5] Phytoremediation of methylmercury pollution:: merB expression in Arabidopsis thaliana confers resistance to organomercurials [J].

Bizily, SP ;

Rugh, CL ;

Summers, AO ;

Meagher, RB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6808-6813

[6] Biochemistry - Harnessing the biosynthetic code: Combinations, permutations, and mutations [J].

Cane, DE ;

Walsh, CT ;

Khosla, C .

SCIENCE, 1998, 282 (5386) :63-68

[7] Introduction: Polyketide and nonribosomal polypeptide biosynthesis. From Collie to coli [J].

Cane, DE .

CHEMICAL REVIEWS, 1997, 97 (07) :2463-2464

[8] The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis [J].

Gehring, AM ;

Mori, I ;

Perry, RD ;

Walsh, CT .

BIOCHEMISTRY, 1998, 37 (33) :11637-11650

[9] Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis [J].

Gerlt, JA ;

Babbitt, PC .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (05) :607-612

[10] Molecular mechanisms of drug inhibition of DNA gyrase [J].

Lewis, RJ ;

Tsai, FTF ;

Wigley, DB .

BIOESSAYS, 1996, 18 (08) :661-671

← 1 2 3 →