Peptide nucleic acid (PNA): A lead for gene therapeutic drugs

被引：20

作者：

Nielsen, PE

机构：

[1] Center for Biomolecular Recognition, Dept. of Med. Biochem. and Genetics, University of Copenhagen, DK-2200 N Copenhagen

来源：

PERSPECTIVES IN DRUG DISCOVERY AND DESIGN | 1996年 / 4卷

关键词：

D O I：

10.1007/BF02172110

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide backbone consisting of aminoethyl glycine units, to which the nucleobases are attached via methylene carbonyl linkers. Excellent RNA and DNA hybridization properties and biological stability, combined with convenient solid phase peptide synthesis, have made PNA a highly interesting lead for gene pharmaceutical drugs. The chemical and biochemical/biological properties in relation to the drug potential of PNA are reviewed.

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页码：76 / 84

页数：9

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