An enantioselective synthesis of β2-amino acid derivatives

被引：33

作者：

Elaridi, J ^{[1
]}

Thaqi, A ^{[1
]}

Prosser, A ^{[1
]}

Jackson, WR ^{[1
]}

Robinson, AJ ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Ctr Green Chem, Clayton, Vic 3800, Australia

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 07期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/j.tetasy.2005.01.048

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantioselective hydrogenation of a series of (E)-alpha-substituted beta-amidoacrylates using Rh(I)-catalysts with chiral phosphine ligands (BPE, DuPHOS) gives beta(2)-amino acid derivatives with enantioselectivities of up to 67%. A beta(2,3)-amino acid derivative was also synthesised with similar enantioselectivity (<= 65%) from the corresponding prochiral enamide. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1309 / 1319

页数：11

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