Ultrahigh resolution OCT imaging with a two-dimensional MEMS scanning endoscope

被引：4

作者：

Aguirre, AD ^{[1
]}

Herz, PR ^{[1
]}

Chen, Y ^{[1
]}

Fujimoto, JG ^{[1
]}

Piyawattanametha, W ^{[1
]}

Fan, L ^{[1
]}

Hsu, ST ^{[1
]}

Fujino, M ^{[1
]}

Wu, MC ^{[1
]}

Kopf, D ^{[1
]}

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

来源：

Advanced Biomedical and Clinical Diagnostic Systems III | 2005年 / 5692卷

关键词：

optical coherence tomography; endoscopy; MEMS;

D O I：

10.1117/12.593143

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper reports preliminary results from the development and application of a two-dimensional MEMS endoscopic scanner for OCT imaging. A 1 min diameter mirror provides high aperture over large scan angle and can scan at rates of hundreds of Hz in both axes. The mirror is integrated with focusing optics and a fiber-optic collimator into a package of similar to 5 mm diameter. Using a broadband femtosecond laser light source, ultrahigh axial image resolution of < 5 um in tissue is achieved at 1.06 um center wavelength. Ultrahigh resolution cross-sectional and three-dimensional OCT imaging is demonstrated with the endoscope with similar to 12 um transverse resolution and < 5 um axial resolution.

引用

页码：277 / 282

页数：6

共 20 条

[1] High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging [J].

Aguirre, AD ;

Hsiung, P ;

Ko, TH ;

Hartl, I ;

Fujimoto, JG .

OPTICS LETTERS, 2003, 28 (21) :2064-2066

[2] High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography [J].

Bouma, BE ;

Tearney, GJ ;

Compton, CC ;

Nishioka, NS .

GASTROINTESTINAL ENDOSCOPY, 2000, 51 (04) :467-474

[3] Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber [J].

Bourquin, S ;

Aguirre, AD ;

Hartl, I ;

Hsiung, P ;

Ko, TH ;

Fujimoto, JG ;

Birks, TA ;

Wadsworth, WJ ;

Bünting, U ;

Kopf, D .

OPTICS EXPRESS, 2003, 11 (24) :3290-3297

[4] Micromachined scanning confocal optical microscope [J].

Dickensheets, DL ;

Kino, GS .

OPTICS LETTERS, 1996, 21 (10) :764-766

[5] A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals [J].

Helmchen, F ;

Fee, MS ;

Tank, DW ;

Denk, W .

NEURON, 2001, 31 (06) :903-912

[6] In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus [J].

Jäckle, S ;

Gladkova, N ;

Feldchtein, F ;

Terentieva, A ;

Brand, B ;

Gelikonov, G ;

Gelikonov, V ;

Sergeev, A ;

Fritscher-Ravens, A ;

Freund, J ;

Seitz, U ;

Schröder, S ;

Soehendra, N .

ENDOSCOPY, 2000, 32 (10) :750-755

[7] Optical coherence tomography: Advanced technology for the endoscopic imaging of Barrett's esophagus [J].

Li, XD ;

Boppart, SA ;

Van Dam, J ;

Mashimo, H ;

Mutinga, M ;

Drexler, W ;

Klein, M ;

Pitris, C ;

Krinsky, ML ;

Brezinski, ME ;

Fujimoto, JG .

ENDOSCOPY, 2000, 32 (12) :921-930

[8] A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope [J].

Miyajima, H ;

Asaoka, N ;

Isokawa, T ;

Ogata, M ;

Aoki, Y ;

Imai, M ;

Fujimori, O ;

Katashiro, M ;

Matsumoto, K .

JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2003, 12 (03) :243-251

[9] Endoscopic optical coherence tomography based on a microelectromechanical mirror [J].

Pan, YT ;

Xie, HK ;

Fedder, GK .

OPTICS LETTERS, 2001, 26 (24) :1966-1968

[10]

PATTERSON PR, 2002, MEMS 2002 IEEE INT C

← 1 2 →