Stressin' Sestrins take an aging fight

被引：198

作者：

Budanou, Andrei V.

Lee, Jun Hee

Karin, Michael ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, San Diego, CA 92103 USA

来源：

EMBO MOLECULAR MEDICINE | 2010年 / 2卷 / 10期

关键词：

aging; p53; redox; Sestrin; target of rapamycin; ACTIVATED PROTEIN-KINASE; EXTENDS LIFE-SPAN; OXIDATIVE STRESS; UP-REGULATION; TRANSCRIPTION FACTORS; ANTIOXIDANT FUNCTION; RAPAMYCIN PROTECTS; HYDROGEN-PEROXIDE; LUNG DEVELOPMENT; AUTOPHAGY GENES;

D O I：

10.1002/emmm.201000097

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sestrins (Sesns) are a family of highly conserved stress-responsive proteins, transcriptionally regulated by p53 and forkhead transcription factor that exhibit oxidoreductase activity in vitro and can protect cells from oxidative stress. However, their major biochemical and physiological function does not appear to depend on their redox (reduction and oxidation) activity. Sesns promote activation of adenosine-5'-monophosphate (AMP)-dependent protein kinase in both mammals and flies. Stress-induced Sesn expression results in inhibition of the target of rapamycin complex 1 (TORC1) and the physiological and pathological implications of disrupting the Sesns-TORC1 crosstalk are now being unravelled. Detailing their mechanism of action and exploring their roles in human physiology point to exciting new insights to topics as diverse as stress, cancer, metabolism and aging.

引用

页码：388 / 400

页数：13

共 115 条

[1] ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS [J].

Alexander, Angela ;

Cai, Sheng-Li ;

Kim, Jinhee ;

Nanez, Adrian ;

Sahin, Mustafa ;

MacLean, Kirsteen H. ;

Inoki, Ken ;

Guan, Kun-Liang ;

Shen, Jianjun ;

Person, Maria D. ;

Kusewitt, Donna ;

Mills, Gordon B. ;

Kastan, Michael B. ;

Walker, Cheryl Lyn .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (09) :4153-4158

[2] ROS up-regulatlion mediates Ras-induced changes of cell morphology and motility [J].

Alexandrova, Antonina Y. ;

Kopnin, Pauel B. ;

Vasiliev, Jury M. ;

Kopnin, Boris P. .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (11) :2066-2073

[3] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[4] Antioxidants put Parkinson flies back in the PINK [J].

Bier, Ethan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (36) :13269-13270

[5] ATP-dependent reduction of cysteine-sulphinic acid by S-cerevisiae sulphiredoxin [J].

Biteau, B ;

Labarre, J ;

Toledano, MB .

NATURE, 2003, 425 (6961) :980-984

[6] Aging ROS or TOR [J].

Blagosklonny, Mikhail V. .

CELL CYCLE, 2008, 7 (21) :3344-3354

[7] Regulation of Protein Synthesis by Ionizing Radiation [J].

Braunstein, Steve ;

Badura, Michelle L. ;

Xi, Qiaoran ;

Formenti, Silvia C. ;

Schneider, Robert J. .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (21) :5645-5656

[8] Rapamycin Inhibits Hepatic Fibrosis in Rats by Attenuating Multiple Profibrogenic Pathways [J].

Bridle, Kim R. ;

Popa, Claudia ;

Morgan, Maelle L. ;

Sobbe, Amy L. ;

Clouston, Andrew D. ;

Fletcher, Linda M. ;

Crawford, Darrell H. G. .

LIVER TRANSPLANTATION, 2009, 15 (10) :1315-1324

[9] Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein [J].

Bryk, R ;

Lima, CD ;

Erdjument-Bromage, H ;

Tempst, P ;

Nathan, C .

SCIENCE, 2002, 295 (5557) :1073-1077

[10] GENE-REGULATION BY TEMPERATURE-SENSITIVE P53 MUTANTS - IDENTIFICATION OF P53 RESPONSE GENES [J].

BUCKBINDER, L ;

TALBOTT, R ;

SEIZINGER, BR ;

KLEY, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (22) :10640-10644

← 1 2 3 4 5 6 7 8 9 10 →