Nuclear Lamins

被引：294

作者：

Dechat, Thomas ^{[1
]}

Adam, Stephen A. ^{[1
]}

Taimen, Pekka

Shimi, Takeshi ^{[1
]}

Goldman, Robert D. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Cell & Mol Biol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 11期

关键词：

A-TYPE LAMINS; DREIFUSS MUSCULAR-DYSTROPHY; MATRIX ATTACHMENT REGIONS; TRANSCRIPTION FACTOR MOK2; CELL-CYCLE PROGRESSION; PROTEIN-KINASE-C; B-TYPE LAMINS; IN-VITRO; DROSOPHILA-MELANOGASTER; INTERMEDIATE-FILAMENTS;

D O I：

10.1101/cshperspect.a000547

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.

引用

页数：22

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