A note on the solution chemistry of carboplatin in aqueous solutions

被引：12

作者：

Lederer, M ^{[1
]}

Leipzig-Pagani, E ^{[1
]}

机构：

[1] Univ Lausanne, BCH, Inst Chim Minerale & Analyt, CH-1015 Lausanne, Switzerland

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 167卷 / 1-2期

关键词：

solution chemistry; carboplatin; aqueous solutions;

D O I：

10.1016/S0378-5173(98)00086-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aging of carboplatin solutions in water, 3.5 and 103 mM NaCl was studied using thin layer chromatography and thin layer electrophoresis. A number of Pt-containing species can be separated, which were not observed in previous work with HPLC. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：223 / 228

页数：6

共 8 条

[1] STABILITY OF CISPLATIN, IPROPLATIN, CARBOPLATIN, AND TETRAPLATIN IN COMMONLY USED INTRAVENOUS SOLUTIONS [J].

CHEUNG, YW ;

CRADOCK, JC ;

VISHNUVAJJALA, BR ;

FLORA, KP .

AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1987, 44 (01) :124-130

[2] TRACE ANALYSIS FOR CIS-PLATINUM ANTI-CANCER DRUGS VIA LCEC [J].

KRULL, IS ;

DING, XD ;

BRAVERMAN, S ;

SELAVKA, C ;

HOCHBERG, F ;

STERNSON, LA .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1983, 21 (04) :166-173

[3] Studies of platinum(II) compounds in aqueous solution.: Part 2.: cis-Pt(NH3)2Cl2 [J].

Lederer, M ;

Leipzig-Pagani, E .

ANALYTICA CHIMICA ACTA, 1998, 358 (01) :61-68

[4] EXTENT OF CISPLATIN FORMATION IN CARBOPLATIN ADMIXTURES [J].

PERRONE, RK ;

KAPLAN, MA ;

BOGARDUS, JB .

AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1989, 46 (02) :258-259

[5] STABILITY OF CARBOPLATIN IN 5-PERCENT GLUCOSE SOLUTION IN GLASS, POLYETHYLENE AND POLYPROPYLENE CONTAINERS [J].

PRAT, J ;

PUJOL, M ;

GIRONA, V ;

MUNOZ, M ;

SOLE, LA .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1994, 12 (01) :81-84

[6] Degradation pathway of carboplatin in aqueous solution [J].

Pujol, M ;

Girona, V ;

Prat, J ;

Munoz, M ;

DeBolos, J .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 146 (02) :263-269

[7] Improved understanding in platinum antitumour chemistry [J].

Reedijk, J .

CHEMICAL COMMUNICATIONS, 1996, (07) :801-806

[8] Separation of platinum(II) anti-tumour drugs by micellar electrokinetic capillary chromatography [J].

Wenclawiak, BW ;

Wollmann, M .

JOURNAL OF CHROMATOGRAPHY A, 1996, 724 (1-2) :317-326

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