Laterality of interhemispheric inhibition depends on handedness

被引:71
作者
Baeumer, T.
Dammann, E.
Bock, F.
Kloeppel, S.
Siebner, H. R.
Muenchau, A.
机构
[1] Univ Hamburg, Dept Neurol, D-20246 Hamburg, Germany
[2] Univ Kiel, Kiel, Germany
关键词
TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; HEMISPHERIC-ASYMMETRY; TRANSCALLOSAL INHIBITION; HUMAN BRAIN; REPRESENTATION; PREMOTOR; HUMANS; EXCITABILITY; ACTIVATION;
D O I
10.1007/s00221-007-0866-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is some evidence that handedness is related to lateralisation of excitability in the motor system. We investigated lateralisation of interhemispheric inhibition (IHI), motor thresholds and short interval intracortical inhibition (SICI) and facilitation (SICF) in relation to handedness in 12 right (RH) and 13 left handed (LH) subjects. Because there is some controversy as to the optimal localisation to produce IHI we also compared IHI induced by conditioning the dorsal premotor cortex (dPM) versus primary motor cortex (M1) in ten RH. IHI was stronger following conditioning the motor dominant as compared to the motor non-dominant hemisphere in RH and LH. Motor thresholds were higher when elicited over the right hemisphere than over the left in both RH and LH, while SICI and SICF showed no differences between hemispheres or dependency from handedness. We hypothesize that IHI is a function of handedness perhaps reflecting predominant usage of the dominant hand, while lateralisation of thresholds and intracortical excitability are determined by other factors.
引用
收藏
页码:195 / 203
页数:9
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