Intracellular organic osmolytes: Function and regulation

被引：493

作者：

Burg, Maurice B. ^{[1
]}

Ferraris, Joan D. ^{[1
]}

机构：

[1] NIH, NHLBI, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2008年 / 283卷 / 12期

关键词：

D O I：

10.1074/jbc.R700042200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells of almost all organisms accumulate organic osmolytes when exposed to hyperosmolality, most often in the form of high salt or urea. In this review, we discuss 1) how the organic osmolytes protect; 2) the identity of osmolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals; 3) the mechanisms by which they are accumulated; 4) sensors of osmolality; 5) the signaling pathways involved; and 6) mutual counteraction by urea and methylamines.

引用

页码：7309 / 7313

页数：5

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