Water promoted, microwave-assisted oxidative novel deamination of N-aminoquinazolinones

被引：8

作者：

Arfan, A. ^{[1
]}

Khan, Rasool ^{[1
]}

Anjum, Shazia ^{[2
]}

Ahmad, Shabir ^{[1
]}

Choudhary, M. Iqbal ^{[2
]}

机构：

[1] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Pakistan

[2] Univ Karachi, Int Ctr Chem & Biol Sci, HEJRIC, Karachi 75270, Pakistan

来源：

CHINESE CHEMICAL LETTERS | 2008年 / 19卷 / 02期

关键词：

N-aminoquinazolinones; oxidative dearnination; KMnO4; water; microwave irradiation;

D O I：

10.1016/j.cclet.2007.10.056

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel deamination of 2-alkyl/aryl 3-amino-4(3H)-quinazolinones series using aqueous KMnO4 under thermal condition and microwave irradiation is described. Compared to thermal condition, significantly higher yields in much shorter times were observed for reactions under microwave irradiation. A plausible mechanism has been proposed for the oxidative water-promoted deamination. (c) 2007 M. Arfan. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：161 / 165

页数：5

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