Effective reductive amination of carbonyl compounds with hydrogen catalyzed by iridium complex in organic solvent and in ionic liquid

被引：75

作者：

Imao, D ^{[1
]}

Fujihara, S ^{[1
]}

Yamamoto, T ^{[1
]}

Ohta, T ^{[1
]}

Ito, Y ^{[1
]}

机构：

[1] Doshisha Univ, Fac Engn, Dept Mol Sci & Technol, Kyoto 6100394, Japan

来源：

TETRAHEDRON | 2005年 / 61卷 / 29期

关键词：

direct reductive amination; iridium; ionic liquid; secondary amine;

D O I：

10.1016/j.tet.2005.05.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct reductive amination (DRA) of carbonyl compounds with amines has been achieved using homogenous iridium catalyst and gaseous hydrogen. It appeared that the cationic iridium catalyst, [Ir(cod)(2)]BF4, without any other ligands was sufficient for the reaction. For the DRA of the ketone substrates, an ionic liquid, [Bmim]BF4, was found to be superior to the other organic solvent used. Especially, the counter anion of the ionic liquid has a significant influence on the selectivity, and at the same time, a high reaction temperature was found to be crucial for the excellent selectivity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6988 / 6992

页数：5

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