Discrimination of Human Astrocytoma Subtypes by Lipid Analysis Using Desorption Electrospray Ionization Imaging Mass Spectrometry

被引：103

作者：

Eberlin, Livia S. ^{[1
,2
]}

Dill, Allison L. ^{[1
,2
]}

Golby, Alexandra J. ^{[3
,4
,5
]}

Ligon, Keith L. ^{[3
,4
,5
]}

Wiseman, Justin M. ^{[6
]}

Cooks, R. Graham ^{[1
,2
]}

Agar, Nathalie Y. R. ^{[3
,4
,5
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Ctr Analyt Instrumentat & Dev, W Lafayette, IN 47907 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurosurg,Dept Radiol, Boston, MA 02115 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med Oncol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[6] Prosolia Inc, Indianapolis, IN 46202 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 34期

基金：

美国国家卫生研究院;

关键词：

gliomas; imaging techniques; molecular pathology; phospholipids; tissue analysis; HUMAN GLIOMAS; BRAIN-TISSUE; IN-VIVO; PROFILES; EXTRACTS;

D O I：

10.1002/anie.201001452

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Figure Presented Differentiation of human brain astrocytic tumor grades can be achieved by direct lipid analysis using desorption electrospray ionization mass spectrometry (DESI-MS). Distinctive lipid profiles are associated with the degree of malignancy, grades II, III, and IV (see picture). © 2010 wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5953 / 5956

页数：4

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