Olfactory bulb in multiple system atrophy

被引：28

作者：

Kovács, T

Papp, MI

Cairns, NJ

Khan, MN

Lantos, PL

机构：

[1] Semmelweis Univ, Dept Neurol, Fac Gen Med, H-1083 Budapest, Hungary

[2] Kings Coll London, Dept Neuropathol, Inst Psychiat, London WC2R 2LS, England

[3] MRC, Neurodegenerat Dis Brain Bank, Dept Neuropathol, Inst Psychiat, London, England

来源：

MOVEMENT DISORDERS | 2003年 / 18卷 / 08期

关键词：

multiple system atrophy; olfactory bulb; glial cytoplasmic inclusion; alpha-synuclein;

D O I：

10.1002/mds.10466

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Olfactory dysfunction is a characteristic clinical sign in Parkinson's disease (PD); it is also present in multiple system atrophy (MSA). The pathological basis of hyposmia or anosmia in PD is well known: the olfactory bulb (OB) contains numerous Lewy bodies and severe neuronal loss is present in the anterior olfactory nucleus (AON). We established that glial cytoplasmic inclusions (GCIs) are present in all the OBs from MSA cases. Their presence in the OB is diagnostic for MSA. Additionally, neuronal loss is present in the AON in MSA. These pathological changes might be responsible for the olfactory dysfunction seen in MSA. (C) 2003 Movement Disorder Society.

引用

收藏

页码：938 / 942

页数：5

相关论文

共 20 条

[1] PRELIMINARY DIAGNOSIS OF PARKINSONS-DISEASE BY OLFACTORY-BULB PATHOLOGY [J].

DANIEL, SE ;

HAWKES, CH .

LANCET, 1992, 340 (8812) :186-186

[2] Immunohistochemical and biochemical studies demonstrate a distinct profile of α-synuclein permutations in multiple system atrophy [J].

Duda, JE ;

Giasson, BI ;

Gur, TL ;

Montine, TJ ;

Robertson, D ;

Biaggioni, I ;

Hurtig, HI ;

Stern, MB ;

Gollomp, SM ;

Grossman, M ;

Lee, VMY ;

Trojanowski, JQ .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2000, 59 (09) :830-841

[3] The expression of α-, β-, and γ-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases [J].

Duda, JE ;

Shah, U ;

Arnold, SE ;

Lee, VMY ;

Trojanowski, JQ .

EXPERIMENTAL NEUROLOGY, 1999, 160 (02) :515-522

[4] Consensus statement on the diagnosis of multiple system atrophy [J].

Gilman, S ;

Low, PA ;

Quinn, N ;

Albanese, A ;

Ben-Shlomo, Y ;

Fowler, CJ ;

Kaufman, H ;

Klockgether, T ;

Lang, AE ;

Lantos, PL ;

Litvan, I ;

Mathias, CJ ;

Oliver, E ;

Robertson, D ;

Schatz, I ;

Wenning, GK .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1999, 163 (01) :94-98

[5] Olfactory dysfunction in Parkinson's disease [J].

Hawkes, CH ;

Shephard, BC ;

Daniel, SE .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (05) :436-446

[6]

Kovács T, 1999, NEUROPATH APPL NEURO, V25, P481

[7] Olfactory centres in Alzheimer's disease:: olfactory bulb is involved in early Braak's stages [J].

Kovács, T ;

Cairns, NJ ;

Lantos, PL .

NEUROREPORT, 2001, 12 (02) :285-288

[8]

McShane RH, 2001, J NEUROL NEUROSUR PS, V70, P739, DOI 10.1136/jnnp.70.6.739

[9] Olfaction in neurodegenerative disease -: A meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases [J].

Mesholam, RI ;

Moberg, PJ ;

Mahr, RN ;

Doty, RL .

ARCHIVES OF NEUROLOGY, 1998, 55 (01) :84-90

[10] Olfactory function in idiopathic Parkinson's disease (IPD):: results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients [J].

Müller, A ;

Reichmann, H ;

Livermore, A ;

Hummel, T .

JOURNAL OF NEURAL TRANSMISSION, 2002, 109 (5-6) :805-811