Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

被引：685

作者：

Encinas, Juan M. ^{[1
]}

Michurina, Tatyana V. ^{[1
]}

Peunova, Natalia ^{[1
]}

Park, June-Hee ^{[1
]}

Tordo, Julie ^{[1
]}

Peterson, Daniel A. ^{[2
,3
]}

Fishell, Gord ^{[4
]}

Koulakov, Alex ^{[1
]}

Enikolopov, Grigori ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] Rosalind Franklin Univ Med & Sci, Ctr Stem Cell & Regenerat Med, N Chicago, IL 60064 USA

[3] Rosalind Franklin Univ Med & Sci, Dept Neurosci, N Chicago, IL 60064 USA

[4] NYU, Sch Med, Smilow Neurosci Program, New York, NY 10016 USA

来源：

CELL STEM CELL | 2011年 / 8卷 / 05期

基金：

美国国家卫生研究院;

关键词：

DENTATE GYRUS; IMMUNOCYTOCHEMICAL ANALYSIS; PROGENITOR CELLS; SELF-RENEWAL; OLD-AGE; NEUROGENESIS; PROLIFERATION; QUIESCENT; NEURONS; BRAIN;

D O I：

10.1016/j.stem.2011.03.010

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous depletion of the neural stem cell pool, as a consequence of their division, may contribute to the age-related decrease in hippocampal neurogenesis. Our results indicate that adult hippocampal stem cells, upon exiting their quiescent state, rapidly undergo a series of asymmetric divisions to produce dividing progeny destined to become neurons and subsequently convert into mature astrocytes. Thus, the decrease in the number of neural stem cells is a division-coupled process and is directly related to their production of new neurons. We present a scheme of the neurogenesis cascade in the adult hippocampus that includes a proposed "disposable stem cell" model and accounts for the disappearance of hippocampal neural stem cells, the appearance of new astrocytes, and the age-related decline in the production of new neurons.

引用

页码：566 / 579

页数：14