Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

被引：3011

作者：

Paolicelli, Rosa C. ^{[1
]}

Bolasco, Giulia ^{[1
]}

Pagani, Francesca ^{[2
,3
]}

Maggi, Laura ^{[2
,3
]}

Scianni, Maria ^{[2
,3
]}

Panzanelli, Patrizia ^{[4
]}

Giustetto, Maurizio ^{[4
,5
]}

Ferreira, Tiago Alves ^{[1
]}

Guiducci, Eva ^{[1
]}

Dumas, Laura ^{[1
]}

Ragozzino, Davide ^{[2
,3
]}

Gross, Cornelius T. ^{[1
]}

机构：

[1] European Mol Biol Lab, Mouse Biol Unit, I-00015 Monterotondo, Italy

[2] Univ Rome, Inst Pasteur, Fdn Cenci Bolognetti, I-00185 Rome, Italy

[3] Univ Rome, Dept Human Physiol & Pharmacol, Ctr Excellence BEMM, I-00185 Rome, Italy

[4] Univ Turin, Dept Anat Pharmacol & Forens Med, I-10124 Turin, Italy

[5] Natl Inst Neurosci, I-10126 Turin, Italy

来源：

SCIENCE | 2011年 / 333卷 / 6048期

关键词：

IN-VIVO; FRACTALKINE RECEPTOR; TARGETED DELETION; RAT HIPPOCAMPUS; CELLS; REVEALS; ELIMINATION; PARENCHYMA; DEATH; FATE;

D O I：

10.1126/science.1202529

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microglia are highly motile phagocytic cells that infiltrate and take up residence in the developing brain, where they are thought to provide a surveillance and scavenging function. However, although microglia have been shown to engulf and clear damaged cellular debris after brain insult, it remains less clear what role microglia play in the uninjured brain. Here, we show that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice. These findings link microglia surveillance to synaptic maturation and suggest that deficits in microglia function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.

引用

页码：1456 / 1458

页数：3

共 30 条

[1] Control of microglial neurotoxicity by the fractalkine receptor [J].

Cardona, Astrid E. ;

Pioro, Erik P. ;

Sasse, Margaret E. ;

Kostenko, Volodymyr ;

Cardona, Sandra M. ;

Dijkstra, Ineke M. ;

Huang, DeRen ;

Kidd, Grahame ;

Dombrowski, Stephen ;

Dutta, RanJan ;

Lee, Jar-Chi ;

Cook, Donald N. ;

Jung, Steffen ;

Lira, Sergio A. ;

Littman, Dan R. ;

Ransohoff, Richard M. .

NATURE NEUROSCIENCE, 2006, 9 (07) :917-924

[2] Potential role of microglia in retinal blood vessel formation [J].

Checchin, Daniella ;

Sennlaub, Florian ;

Levavasseur, Etienne ;

Leduc, Martin ;

Chemtob, Sylvain .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (08) :3595-3602

[3] Enhanced synaptic connectivity and epilepsy in C1q knockout mice [J].

Chu, Yunxiang ;

Jin, Xiaoming ;

Parada, Isabel ;

Pesic, Alexei ;

Stevens, Beth ;

Barres, Ben ;

Prince, David A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (17) :7975-7980

[4] Delayed Stabilization of Dendritic Spines in Fragile X Mice [J].

Cruz-Martin, Alberto ;

Crespo, Michelle ;

Portera-Cailliau, Carlos .

JOURNAL OF NEUROSCIENCE, 2010, 30 (23) :7793-7803

[5]

Dalmau I, 1998, HIPPOCAMPUS, V8, P458, DOI 10.1002/(SICI)1098-1063(1998)8:5<458::AID-HIPO6>3.0.CO

[6]

2-N

[7] ATP mediates rapid microglial response to local brain injury in vivo [J].

Davalos, D ;

Grutzendler, J ;

Yang, G ;

Kim, JV ;

Zuo, Y ;

Jung, S ;

Littman, DR ;

Dustin, ML ;

Gan, WB .

NATURE NEUROSCIENCE, 2005, 8 (06) :752-758

[8] Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages [J].

Ginhoux, Florent ;

Greter, Melanie ;

Leboeuf, Marylene ;

Nandi, Sayan ;

See, Peter ;

Gokhan, Solen ;

Mehler, Mark F. ;

Conway, Simon J. ;

Ng, Lai Guan ;

Stanley, E. Richard ;

Samokhvalov, Igor M. ;

Merad, Miriam .

SCIENCE, 2010, 330 (6005) :841-845

[9] Changing Face of Microglia [J].

Graeber, Manuel B. .

SCIENCE, 2010, 330 (6005) :783-788

[10] Microglia: active sensor and versatile effector cells in the normal and pathologic brain [J].

Hanisch, Uwe-Karsten ;

Kettenmann, Helmut .

NATURE NEUROSCIENCE, 2007, 10 (11) :1387-1394

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