Detection of acute renal ischemia in swine using blood oxygen level-dependent magnetic resonance imaging

被引:46
作者
Alford, SK
Sadowski, EA
Unal, O
Polzin, JA
Consigny, DW
Korosec, FR
Grist, TM
机构
[1] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53792 USA
[2] Univ Wisconsin, Dept Radiol, Madison, WI 53792 USA
[3] GE Med Syst, Milwaukee, WI USA
关键词
BOLD MRI; blood oxygenation; kidney; renal ischemia; medulla;
D O I
10.1002/jmri.20389
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To determine the feasibility and sensitivity of blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) to detect acute renal ischemia, using a swine model, and to present the causes of variability and assess techniques that minimize variability introduced during data analysis. Materials and Methods: BOLD MRI was performed in axial and coronal planes of the kidneys of five swine. Color R2* maps were calculated and mean R2* values and 95% confidence intervals (CIs) for the cortex and medulla were determined for baseline, renal artery occlusion and reperfusion conditions. Paired Student's t-tests were used to determine significance. Results: Mean R2* measurements increased from baseline during renal artery occlusion in the cortex (axial, 13.8-24.6 second(-1); coronal, 14.4-24.7 second(-1)) and medulla (axial, 19.3-32.2 second(-1): coronal, 20.1-30.7 second(-1)). These differences were significant for both the cortex (axial, P < 0.04; coronal, P < 0.005) and medulla (axial, P < 0.02; coronal, P < 0.0005). No significant change was observed in the contralateral kidney. Conclusion: R2* values were significantly higher than baseline for medulla and cortex during renal artery occlusion. More variability exists in R2* measurements in the medulla than the cortex and in the axial than the coronal plane.
引用
收藏
页码:347 / 353
页数:7
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