Dopamine transporter: Basic aspects and neuroimaging

被引：61

作者：

Piccini, PP

机构：

[1] Hammersmith Hosp, Imperial Coll Sci Technol & Med, Fac Med, PET Neurol Grp,MRC Clin Sci Ctr, London W12 0NN, England

[2] Hammersmith Hosp, Imperial Coll Sci Technol & Med, Fac Med, Div Neurosci, London W12 0NN, England

来源：

MOVEMENT DISORDERS | 2003年 / 18卷

基金：

英国医学研究理事会;

关键词：

dopamine transporter; radiotracers; neuroimaging; PET; SPECT;

D O I：

10.1002/mds.10571

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The plasma membrane dopamine transporter (DAT) is found exclusively in dopamine neurones and seems to be the defining molecule of the dopamine neurone. It provides effective control over the intensity of dopamine-mediated signalling by recapturing the neurotransmitter released by presynaptic neurones. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) represent unique techniques for assessing in vivo DAT distribution in humans and offer reliable methods for studying nigrostriatal dopaminergic function in health and disease. The characteristics of different DAT radiotracers, the modifying influences of factors such as age, gender, smoking habit, and dopaminergic drugs on DAT transporters as well as their implication in evaluation of neuroimaging studies are discussed. (C) 2003 Movement Disorder Society.

引用

页码：S3 / S8

页数：6

共 67 条

[51] [I-123] 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE - HIGH-AFFINITY SPECT RADIOTRACER OF MONOAMINE REUPTAKE SITES IN BRAIN [J].

NEUMEYER, JL ;

WANG, SY ;

MILIUS, RA ;

BALDWIN, RM ;

ZEAPONCE, Y ;

HOFFER, PB ;

SYBIRSKA, E ;

ALTIKRITI, M ;

CHARNEY, DS ;

MALISON, RT ;

LARUELLE, M ;

INNIS, RB .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (10) :3144-3146

[52]

Nirenberg MJ, 1996, J NEUROSCI, V16, P436

[53]

Pristupa ZB, 1998, SYNAPSE, V30, P79, DOI 10.1002/(SICI)1098-2396(199809)30:1<79::AID-SYN10>3.0.CO

[54]

2-K

[55] AMPHETAMINE - EFFECTS ON CATECHOLAMINE SYSTEMS AND BEHAVIOR [J].

SEIDEN, LS ;

SABOL, KE .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1993, 33 :639-677

[56] MOLECULAR MECHANISMS OF DRUG REINFORCEMENT AND ADDICTION [J].

SELF, DW ;

NESTLER, EJ .

ANNUAL REVIEW OF NEUROSCIENCE, 1995, 18 :463-495

[57] CLONING AND EXPRESSION OF A COCAINE-SENSITIVE DOPAMINE TRANSPORTER COMPLEMENTARY-DNA [J].

SHIMADA, S ;

KITAYAMA, S ;

LIN, CL ;

PATEL, A ;

NANTHAKUMAR, E ;

GREGOR, P ;

KUHAR, M ;

UHL, G .

SCIENCE, 1991, 254 (5031) :576-578

[58] Sex differences in [123I]β-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers [J].

Staley, JK ;

Krishnan-Sarin, S ;

Zoghbi, S ;

Tamagnan, G ;

Fujita, M ;

Seibyl, JP ;

Maciejewski, PK ;

O'Malley, S ;

Innis, RB .

SYNAPSE, 2001, 41 (04) :275-284

[59]

SULZER D, 1995, J NEUROSCI, V15, P4102

[60] Pharmacological modifications of dopamine transmission do not influence the striatal in vivo binding of [H-3]mazindol or [H-3]cocaine in mice [J].

Thibaut, F ;

Bonnet, JJ ;

Vaugeois, JM ;

Costentin, J .

NEUROSCIENCE LETTERS, 1996, 205 (03) :145-148

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