Thiourea-catalyzed enantioselective cyanosilylation of ketones

被引：310

作者：

Fuerst, DE ^{[1
]}

Jacobsen, EN ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02318 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 25期

关键词：

D O I：

10.1021/ja052511x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The new chiral amino thiourea catalyst 3d promotes the highly enantioselective cyanosilylation of a wide variety of ketones. The hindered tertiary amine substituent plays a crucial role with regard to both stereoinduction and reactivity, suggesting a cooperative mechanism involving electrophile activation by thiourea and nucleophile activation by the amine. Copyright © 2005 American Chemical Society.

引用

页码：8964 / 8965

页数：2

共 45 条

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