Automated Three-dimensional Quantification of Noncalcified Coronary Plaque from Coronary CT Angiography: Comparison with Intravascular US

被引：180

作者：

Dey, Damini ^{[1
,2
]}

Schepis, Tiziano ^{[3
]}

Marwan, Mohamed ^{[3
]}

Slomka, Piotr J. ^{[1
,2
]}

Berman, Daniel S. ^{[1
,2
]}

Achenbach, Stephan ^{[3
]}

机构：

[1] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Imaging, Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90048 USA

[3] Univ Erlangen Nurnberg, Dept Internal Med 2, Erlangen, Germany

来源：

RADIOLOGY | 2010年 / 257卷 / 02期

关键词：

64-SLICE COMPUTED-TOMOGRAPHY; ATHEROSCLEROTIC PLAQUE; INTRACORONARY ULTRASOUND; MDCT ANGIOGRAPHY; DISEASE EVENTS; VOXEL ANALYSIS; CALCIUM; ACCURACY; ARTERIES; IVUS;

D O I：

10.1148/radiol.10100681

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To determine the accuracy of a previously developed automated algorithm (AUTOPLAQ [APQ]) for rapid volumetric quantification of noncalcified and calcified plaque from coronary computed tomographic (CT) angiography in comparison with intravascular ultrasonography (US). Materials and Methods: This study was approved by the institutional review board and was HIPAA compliant; all patients provided written informed consent. APQ combines derived scan-specific attenuation threshold levels for lumen, plaque, and knowledge-based segmentation of coronary arteries for quantification of plaque components. APQ was validated with retrospective analysis of 22 coronary atherosclerotic plaques in 20 patients imaged with coronary CT angiography and intravascular US within 2 days of each other. Coronary CT angiographic data were acquired by using dual-source CT. For each patient, well-defined plaques without calcifications were selected, and plaque volume was measured with APQ and manual tracing at CT and with intravascular US. Measurements were compared with paired t test, correlation, and Bland-Altman analysis. Results: There was excellent correlation between noncalcified plaque volumes quantified with APQ and intravascular US (r = 0.94, P < .001), with no significant differences (P = .08). Mean plaque volume with intravascular US was 105.9 mm(3) +/- 83.5 (standard deviation) and with APQ was 116.6 mm(3) +/- 80.1. Mean plaque volume with manual tracing from CT was 100.8 mm(3) +/- 81.7 and with APQ was 116.6 mm(3) +/- 80.1, with excellent correlation (r = 0.92, P < .001) and no significant differences (P = .23). Conclusion: Automated scan-specific threshold level-based quantification of plaque components from coronary CT angiography allows rapid, accurate measurement of noncalcified plaque volumes, compared with intravascular US, and requires a fraction of the time needed for manual analysis. (C) RSNA, 2010

引用

页码：516 / 522

页数：7

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