Compositional heterogeneity within, and uniformity between, DNA sequences of yeast chromosomes

被引：60

作者：

Li, WT

Stolovitzky, G

Bernaola-Galván, P

Oliver, JL

机构：

[1] Rockefeller Univ, Lab Stat Genet, New York, NY 10021 USA

[2] Rockefeller Univ, Ctr Studies Phys & Biol, New York, NY 10021 USA

[3] Univ Malaga, Dept Appl Phys 2, E-29071 Malaga, Spain

[4] Univ Granada, Dept Genet, E-18071 Granada, Spain

[5] Univ Granada, Inst Biotechnol, E-18071 Granada, Spain

来源：

GENOME RESEARCH | 1998年 / 8卷 / 09期

关键词：

D O I：

10.1101/gr.8.9.916

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The heterogeneity within, and similarities between, yeast chromosomes are studied. For the former, we show by the size distribution of domains, coding density, size distribution of open reading frames, spatial power spectra, and deviation from binomial distribution For C + G% in large moving windows that there is a strong deviation of the yeast sequences from random sequences. For the latter, not only do we graphically illustrate the similarity for the above mentioned statistics, but we also carry out a rigorous analysis of variance (ANOVA) test. The hypothesis that all yeast chromosomes are similar cannot be rejected by this test. We examine the two possible explanations of this interchromosomal uniformity: a common origin, such as genome-wide duplication (polyploidization), and a concerted evolutionary process.

引用

页码：916 / 928

页数：13

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