The dilute locus and Griscelli syndrome:: Gateways towards a better understanding of melanosome transport

被引：27

作者：

Westbroek, W ^{[1
]}

Lambert, J ^{[1
]}

Naeyaert, JM ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Dermatol, B-9000 Ghent, Belgium

来源：

PIGMENT CELL RESEARCH | 2001年 / 14卷 / 05期

关键词：

actin; melanocyte; motor proteins; tubulin;

D O I：

10.1034/j.1600-0749.2001.140503.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this review an overview of recent advances in the understanding of melanosome movement within epidermal melanocytes is given. Exploration of the molecular events involved in and determining the process of melanosome transport, as an essential part of human pigmentation, could lead to the identification of agents that augment, or down-regulate the transfer of melanosomes to surrounding keratinocytes. This would present a major breakthrough in the possibilities to influence pigmentation and related disorders, of great concern to some patients. Moreover, melanosome transport offers a good model to study mammalian organelle trafficking and its key players in general.

引用

页码：320 / 327

页数：8

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