Relationship between protein structures and disulfide bonding patterns

被引：53

作者：

Chuang, CC

Chen, CY

Yang, JM

Lyu, PC

Hwang, JK ^{[1
]}

机构：

[1] Natl Chiao Tung Univ, Inst Bioinformat, Dept Biol Sci & Technol, Hsinchu, Taiwan

[2] Natl Tsing Hua Univ, Dept Life Sci, Inst Bioinformat & Struct Biol, Hsinchu, Taiwan

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2003年 / 53卷 / 01期

关键词：

disulfide-bonding patterns; the hierarchical clustering method; structure classification;

D O I：

10.1002/prot.10492

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We found that that disulfide-bonding patterns can be used to discriminate structure similarity. Our method, based on the hierarchical clustering scheme, is applicable to proteins with two or more disulfide bonds and is able to detect the structural similarities of proteins of low sequence identities (<25%). Our results show the surprisingly close relationship between disulfide-bonding patterns and proteins structures. Our findings should be useful in protein structure modeling. (C) 2003 Wiley-Liss, Inc.

引用

页码：1 / 5

页数：5

共 42 条

[11] ENGINEERED DISULFIDE BONDS AS PROBES OF THE FOLDING PATHWAY OF BARNASE - INCREASING THE STABILITY OF PROTEINS AGAINST THE RATE OF DENATURATION [J].