Al(OH)3 facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

被引：23

作者：

Cui, X. ^{[1
]}

Green, M. A. ^{[1
,2
]}

Blower, P. J. ^{[1
]}

Zhou, D. ^{[3
]}

Yan, Y. ^{[4
]}

Zhang, W. ^{[5
]}

Djanashvili, K. ^{[5
]}

Mathe, D. ^{[6
]}

Veres, D. S. ^{[7
]}

Szigeti, K. ^{[7
]}

机构：

[1] Kings Coll London, St Thomas Hosp, Div Imaging Sci & Biomed Engn, London SE1 7EH, England

[2] Kings Coll London, Dept Phys, London WC2R 2LS, England

[3] Univ Loughborough, Dept Math Sci, Loughborough LE11 3TU, Leics, England

[4] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[5] Delft Univ Technol, Dept Biotechnol, NL-2628 BL Delft, Netherlands

[6] CROmed Ltd, H-1047 Budapest, Hungary

[7] Semmelweis Univ, Dept Biophys & Radiat Biol, H-1094 Budapest, Hungary

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 45期

基金：

英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

MRI; AGENT;

D O I：

10.1039/c5cc02259b

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)(3)-stabilised MnFe2O4 or Fe3O4 nanoparticles as precursors. They were readily and efficiently radiolabelled with F-18. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with Cu-64.

引用

页码：9332 / 9335

页数：4

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