Lipid droplets: a classic organelle with new outfits

被引：267

作者：

Fujimoto, Toyoshi ^{[1
]}

Ohsaki, Yuki ^{[1
]}

Cheng, Jinglei ^{[1
]}

Suzuki, Michitaka ^{[1
]}

Shinohara, Yuki ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Anat & Mol Cell Biol, Nagoya, Aichi 4668550, Japan

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2008年 / 130卷 / 02期

关键词：

lipid droplet; lipid ester; phospholipid; cholesterol; PAT protein; caveolin;

D O I：

10.1007/s00418-008-0449-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lipid droplets are depots of neutral lipids that exist virtually in any kind of cell. Recent studies have revealed that the lipid droplet is not a mere lipid blob, but a major contributor not only to lipid homeostasis but also to diverse cellular functions. Because of the unique structure as well as the functional importance in relation to obesity, steatosis, and other prevailing diseases, the lipid droplet is now reborn as a brand new organelle, attracting interests from researchers of many disciplines.

引用

页码：263 / 279

页数：17

共 147 条

[1] Genetic disorders of adipose tissue development, differentiation, and death [J].

Agarwal, Anil K. ;

Garg, Abhimanyu .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2006, 7 :175-199

[2] PLD1 and ERK2 regulate cytosolic lipid droplet formation [J].

Andersson, Linda ;

Bostrom, Pontus ;

Ericson, Johanna ;

Rutberg, Mikael ;

Magnusson, Bjorn ;

Marchesan, Denis ;

Ruiz, Michel ;

Asp, Lennart ;

Huang, Ping ;

Frohman, Michael A. ;

Boren, Jan ;

Olofsson, Sven-Olof .

JOURNAL OF CELL SCIENCE, 2006, 119 (11) :2246-2257

[3] IMIDAZOLE-BUFFERED OSMIUM-TETROXIDE - AN EXCELLENT STAIN FOR VISUALIZATION OF LIPIDS IN TRANSMISSION ELECTRON-MICROSCOPY [J].

ANGERMULLER, S ;

FAHIMI, HD .

HISTOCHEMICAL JOURNAL, 1982, 14 (05) :823-835

[4] Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method [J].

Baba, M ;

Osumi, M ;

Ohsumi, Y .

CELL STRUCTURE AND FUNCTION, 1995, 20 (06) :465-471

[5] Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets [J].

Barba, G ;

Harper, F ;

Harada, T ;

Kohara, M ;

Goulinet, S ;

Matsuura, Y ;

Eder, G ;

Schaff, Z ;

Chapman, MJ ;

Miyamura, T ;

Brechot, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) :1200-1205

[6] Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic [J].

Bartz, Rene ;

Li, Wen-Hong ;

Venables, Barney ;

Zehmer, John K. ;

Roth, Mary R. ;

Welti, Ruth ;

Anderson, Richard G. W. ;

Liu, Pingsheng ;

Chapman, Kent D. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (04) :837-847

[7] An intimate collaboration between peroxisomes and lipid bodies [J].

Binns, Derk ;

Januszewski, Tom ;

Chen, Yue ;

Hill, Justin ;

Markin, Vladislav S. ;

Zhao, Yingming ;

Gilpin, Christopher ;

Chapman, Kent D. ;

Anderson, Richard G. W. ;

Goodman, Joel M. .

JOURNAL OF CELL BIOLOGY, 2006, 173 (05) :719-731

[8]

BLANCHETTEMACKIE EJ, 1995, J LIPID RES, V36, P1211

[9] Cytosolic lipid droplets increase in size by microtubule-dependent complex formation [J].

Boström, P ;

Rutberg, M ;

Ericsson, J ;

Holmdahl, P ;

Andersson, L ;

Frohman, MA ;

Borén, J ;

Olofsson, SO .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (09) :1945-1951

[10] SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity [J].

Bostrom, Pontus ;

Andersson, Linda ;

Rutberg, Mikael ;

Perman, Jeanna ;

Lidberg, Ulf ;

Johansson, Bengt R. ;

Fernandez-Rodriguez, Julia ;

Ericson, Johanna ;

Nilsson, Tommy ;

Boren, Jan ;

Olofsson, Sven-Olof .

NATURE CELL BIOLOGY, 2007, 9 (11) :1286-U139

← 1 2 3 4 5 6 7 8 9 10 →