Lipid droplets: a classic organelle with new outfits

被引：267

作者：

Fujimoto, Toyoshi ^{[1
]}

Ohsaki, Yuki ^{[1
]}

Cheng, Jinglei ^{[1
]}

Suzuki, Michitaka ^{[1
]}

Shinohara, Yuki ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Anat & Mol Cell Biol, Nagoya, Aichi 4668550, Japan

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2008年 / 130卷 / 02期

关键词：

lipid droplet; lipid ester; phospholipid; cholesterol; PAT protein; caveolin;

D O I：

10.1007/s00418-008-0449-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lipid droplets are depots of neutral lipids that exist virtually in any kind of cell. Recent studies have revealed that the lipid droplet is not a mere lipid blob, but a major contributor not only to lipid homeostasis but also to diverse cellular functions. Because of the unique structure as well as the functional importance in relation to obesity, steatosis, and other prevailing diseases, the lipid droplet is now reborn as a brand new organelle, attracting interests from researchers of many disciplines.

引用

页码：263 / 279

页数：17

共 147 条

[41] A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament assembly [J].

Giasson, BI ;

Murray, IVJ ;

Trojanowski, JQ ;

Lee, VMY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) :2380-2386

[42] Mobilisation of triacylglycerol stores [J].

Gibbons, GF ;

Islam, K ;

Pease, RJ .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1483 (01) :37-57

[43] FACTORS UNDERLYING THE VARIABILITY OF LIPID DROPLET FLUORESCENCE IN MA-10 LEYDIG TUMOR-CELLS [J].

GOCZE, PM ;

FREEMAN, DA .

CYTOMETRY, 1994, 17 (02) :151-158

[44]

GREENBERG AS, 1991, J BIOL CHEM, V266, P11341

[45] NILE RED - A SELECTIVE FLUORESCENT STAIN FOR INTRACELLULAR LIPID DROPLETS [J].

GREENSPAN, P ;

MAYER, EP ;

FOWLER, SD .

JOURNAL OF CELL BIOLOGY, 1985, 100 (03) :965-973

[46] 1H NMR visible lipids in the life and death of cells [J].

Hakumäki, JM ;

Kauppinen, RA .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (08) :357-362

[47] Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane [J].

Heid, HW ;

Schnolzer, M ;

Keenan, TW .

BIOCHEMICAL JOURNAL, 1996, 320 :1025-1030

[48] Structure of low density lipoprotein (LDL) particles:: Basis for understanding molecular changes in modified LDL [J].

Hevonoja, T ;

Pentikäinen, MO ;

Hyvönen, MT ;

Kovanen, PT ;

Ala-Korpela, M .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1488 (03) :189-210

[49] Structure of a lipid droplet protein: The PAT family member TIP47 [J].

Hickenbottom, SJ ;

Kimmel, AR ;

Londos, C ;

Hurley, JH .

STRUCTURE, 2004, 12 (07) :1199-1207

[50]

KAYE GWC, 1995, TABLES PHYS CHEM COM

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