Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry

被引：80

作者：

Rosu, F

Gabelica, V

Shin-ya, K

De Pauw, E

机构：

[1] Univ Liege, Dept Chem, B-4000 Liege, Belgium

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 21期

关键词：

D O I：

10.1039/b309394h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrospray mass spectrometry (ESI-MS) was used to monitor the kinetics of duplex formation between the human telomeric DNA quadruplex and its complementary strand; the complexation of telomestatin to the G-quadruplex delays the unwinding of the quadruplex structure and formation of the duplex.

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页码：2702 / 2703

页数：2

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