Structural basis for control by phosphorylation

被引：512

作者：

Johnson, LN ^{[1
]}

Lewis, RJ ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Mol Biophys Lab, Oxford OX1 3QU, England

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000225s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intracellular phosphorylation by protein kinases, triggered in response to extracellular signals which provided a mechanism for the cell to switch on or switch off many diverse processes was investigated. The processes which included metabolic pathways, kinase cascade activation, membrane transport, gene transcription and motor mechanisms were also studied. The structural studies on protein kinases showed that the peptide substrate in the vicinity of the phosphorylatable residue possessed defined extended conformation.

引用

页码：2209 / 2242

页数：34

共 177 条

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