Tools for microwave-assisted parallel syntheses and combinatorial chemistry

被引：34

作者：

Nuechter, Matthias ^{[1
]}

Ondruschka, Bernd ^{[1
]}

机构：

[1] Univ Jena, Inst Tech Chem & Environm Chem, D-07743 Jena, Germany

来源：

MOLECULAR DIVERSITY | 2003年 / 7卷 / 2-4期

关键词：

condensation; equipment for parallel synthesis; esterification; heterocyclic compounds; microwave-assisted reaction; setup for combinatorial chemistry;

D O I：

10.1023/B:MODI.0000006916.69862.3d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A protocol for transferring conventional reactions to the microwave field explores the effectiveness of parallel syntheses and combination approaches. Applicability to the reaction systems combiCHEM, multiPREP, MMR8 and HPR is defined. Model reactions have been performed in laboratory equipment. Emphasis is placed on similar reaction conditions in the individual vessels and the repeatability of results. Outcomes include esterifications and multi-center reactions exhibiting a great potential for combinatorial chemistry.

引用

页码：253 / 264

页数：12

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