Multisite bone ultrasound measurement on North American female reference population

The Sunlight Omnisense is a portable quantitative ultrasound device that measures speed of sound (SOS) at multiple skeletal sites and therefore has the potential to provide a more complete assessment of an individual's overall fracture risk than single-site measurements such as the calcaneus. To provide a robust normative female database, 545 healthy Caucasian women ages 20-90 were recruited at five centers across North America. SOS measurements were obtained from the distal one-third radius, proximal third phalanx, midshaft tibia, and fifth metatarsal The results demonstrate that peak SOS occurs around the age of 40, with maximum mean values of 4161, 3928, 3786, and 4092 m/s seen at the radius, tibia, metatarsal, and phalanx, respectively. Maximal rate of decline of SOS was seen in the decade following menopause (-12.4, -9.2, -12.1, and -18.8 m/s at the radius, tibia, metatarsal, and phalanx, respectively). Reproducibility between successive measurements indicates high precision, with standardized coefficients of variance ranging between 1.5 and 4.5%. Greatest precision was seen at the metatarsal. Further work is required to clarify the biologic significance of multisite SOS measurements and their use in the assessment of fracture risk.