Nitazoxanide: A new thiazolide antiparasitic agent

被引：305

作者：

Fox, LM

Saravolatz, LD

机构：

[1] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA

[2] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA

[3] St Johns Hosp, Dept Med, Detroit, MI USA

[4] Wayne State Univ, Sch Med, Detroit, MI USA

来源：

CLINICAL INFECTIOUS DISEASES | 2005年 / 40卷 / 08期

关键词：

D O I：

10.1086/428839

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. At present, there are no documented drug-drug interactions. Nitazoxanide has been licensed for the treatment of Giardia intestinalis-induced diarrhea in patients >= 1 year of age and Cryptosporidum-induced diarrhea in children aged 1-11 years. At present, it is pending licensure for treatment of infection due to Cryptosporidium species in adults and for use in treating immunocompromised hosts. It represents an important addition to the antiparasitic arsenal.

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页码：1173 / 1180

页数：8

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