Could physical exercises modulate Nrf2-Keapl pathway in chronic kidney disease?

被引：19

作者：

Abreu, C. C. ^{[1
]}

Cardozo, L. F. M. F. ^{[1
]}

Mafra, D. ^{[1
]}

机构：

[1] Univ Fed Fluminense, Grad Program Cardiovasc Sci, Niteroi, RJ, Brazil

来源：

MEDICAL HYPOTHESES | 2015年 / 84卷 / 01期

关键词：

NF-KAPPA-B; OXIDATIVE STRESS; SKELETAL-MUSCLE; NRF2; INFLAMMATION; ACTIVATION; MECHANISMS; CANCER;

D O I：

10.1016/j.mehy.2014.11.013

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Patients with chronic kidney disease (CKD) have various metabolic disorders caused by a chronic state of oxidative stress and inflammation, and recently, nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as a factor that plays a significant role in cellular protection against oxidative stress and inflammation. This transcription factor when activated can regulate antioxidant and anti-inflammatory cellular responses leading to the expression of detoxifying enzymes. Studies have shown that Nrf2 expression can be modulated by several factors, such as bioactive compounds and physical exercise. In fact, exercise in CKD patients can bring many benefits; however, there are no studies correlating physical activity and Nrf2 expression in CKD patients. This review aims to discuss whether there is any evidence to justify a recommendation of physical exercise in CKD patients as a non-pharmacological option to activate the Nrf2 pathway. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：44 / 46

页数：3

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