The RNA coregulator SRA, its binding proteins and nuclear receptor signaling activity

被引：25

作者：

Colley, Shane M. ^{[1
,2
]}

Iyer, Kavitha R. ^{[1
,2
,3
]}

Leedman, Peter J. ^{[1
,2
,3
]}

机构：

[1] Western Australian Inst Med Res, Lab Canc Med, Perth, WA 6000, Australia

[2] Univ Western Australia, Med Res Ctr, Nedlands, WA 6009, Australia

[3] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia

来源：

IUBMB LIFE | 2008年 / 60卷 / 03期

关键词：

SRA; RNA-binding proteins; SLIRP; coregulators; nuclear receptor;

D O I：

10.1002/iub.22

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear receptor (NR) coregulators are key modulators of hormone signaling. Discovery of steroid receptor RNA activator (SRA), a coregulator that is active as a RNA, transformed thinking in the field of hormone action. The subsequent identification of SRA-binding coregulator proteins, including p68, SHARP and more recently SLIRP, has provided important insight into SRA's mechanism of action and potentially offers new opportunities to target NR signaling pathways for therapeutic gain. Here we outline advances in the field of NR coregulator biology, with a bias on recent progress in understanding SRA-protein interactions. (C) 2008 IUBMB.

引用

收藏

页码：159 / 164

页数：6

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