Antifungal amide from leaves of Piper hispidum

被引：71

作者：

Alécio, AC

Bolzani, VD

Young, MCM

Kato, MJ

Furlan, M

机构：

[1] Univ Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil

[2] Inst Bot, Secao Fisiol & Bioquim Plantas, BR-01061970 Sao Paulo, SP, Brazil

[3] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo, SP, Brazil

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 05期

关键词：

D O I：

10.1021/np9703656

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-guided fractionation of a CH2Cl2 extract from leaves of Piper hispidum (Piperaceae) yielded a new pyrrolidine amide, N-[7-(3',4'-methylenedioxyphenyl)-2(Z),4(Z)-heptadienoyl] pyrrolidine 1, in addition to two known amides N-[5-(3',4'-methylenedioxyphenyl)-2(E)-pentadienoyl]pyrrolidine and N-[2-(3',4'-methylenedioxy-6'-methoxyphenyl)-2(Z)-propenoyl]pyrrolidine. The structure of compound 1 was elucidated by interpretation of spectral data, including ES-MS. Compound 1 showed antifungal activity against Cladosporium sphaerospermum.

引用

页码：637 / 639

页数：3

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