Fused heterocyclic amido compounds as anti-hepatitis C virus agents

被引：22

作者：

Aoyama, Hiroshi ^{[1
]}

Sugita, Kazuyuki ^{[1
]}

Nakamura, Masahiko ^{[1
]}

Aoyama, Atsushi ^{[1
]}

Salim, Mohammed T. A. ^{[2
]}

Okamoto, Mika ^{[2
]}

Baba, Masanori ^{[2
]}

Hashimoto, Yuichi ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Ctr Chron Viral Dis, Div Antiviral Chemotherapy, Kagoshima 8908544, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 08期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

Hepatitis C virus; Phenanthridine; Anti-HCV agent; Methoxy; 1,3-Dioxolyl; VIRAL DIARRHEA VIRUS; BVDV; EPIDEMIOLOGY; COMBINATION; DERIVATIVES; INHIBITION; INTERFERON; RIBAVIRIN; AMINES; POTENT;

D O I：

10.1016/j.bmc.2011.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We identified a fused heteroaromatic amido structure based on the phenanthridine skeleton as a superior scaffold for candidate drugs with potent anti-HCV activity. Among the compounds synthesized, a phenanthridine analogue with a 1,3-dioxolyl group (24) possessed the most potent anti-HCV activity (EC50 value: 50 nM), with acceptable cytotoxicity. The structural development and structure-activity relationships of these compounds are described. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2675 / 2687

页数：13

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