POLYMETHYLATED γ-CARBOLINES WITH POTENT ANTI-BOVINE VIRAL DIARRHEA VIRUS (BVDV) ACTIVITY

被引：8

作者：

Aoyama, Hiroshi ^{[1
]}

Sako, Kumiko ^{[1
]}

Sato, Shinichi ^{[1
]}

Nakamura, Masahiko ^{[1
]}

Miyachi, Hiroyuki ^{[1
]}

Goto, Yukinori ^{[2
]}

Okamoto, Mika ^{[2
]}

Baba, Masanori ^{[2
]}

Hashimoto, Yuichi ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Div Antiviral Chemotherapy, Ctr Chron Viral Dis, Kagoshima 8908544, Japan

来源：

HETEROCYCLES | 2009年 / 77卷 / 02期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

Anti-BVDV Agent; gamma-Carboline; Quantitative Structure-Activity Relationship (QSAR); Buchwaid-Hartwig Amination; Palladium-Catalyzed; HEPATITIS-C VIRUS; COMBINATION; INFECTION; PATHOGENESIS; RIBAVIRIN;

D O I：

10.3987/COM-08-S(F)68

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several anti-BVDV agents with a polymethylated gamma-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.

引用

页码：779 / 785

页数：7

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