学术探索
学术期刊
新闻热点
数据分析
智能评审

Introduction to micro-analytical systems: bioanalytical and pharmaceutical applications

被引：129
作者：
Huikko, K
Kostiainen, R
Kotiaho, T
机构：
[1] Univ Helsinki, Dept Pharm, Vikki Drug Discovery Technol Ctr, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Dept Pharm, Div Pharmaceut Chem, FIN-00014 Helsinki, Finland
来源：
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2003年 / 20卷 / 02期
关键词：
fabrication technology; analytical instruments; miniaturization;
D O I：
10.1016/S0928-0987(03)00147-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This review presents a brief overview of recent developments in miniaturization of analytical instruments utilizing microfabrication technology. The concept 'Micro-Total Analysis Systems (mu-TAS)', also termed 'Lab-on-a-chip', and the latest progresses in the development of microfabricated separation devices and on-chip detection techniques are discussed. Applications of micro-analytical methods to bioanalytical and pharmaceutical studies are also described, including chemical reactions, assays, and analytical separations of biomolecules in micro-scale. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：149 / 171
页数：23
相关论文
共 164 条
[1]   Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping [J].
Anderson, JR ;
Chiu, DT ;
Jackman, RJ ;
Cherniavskaya, O ;
McDonald, JC ;
Wu, HK ;
Whitesides, SH ;
Whitesides, GM .
ANALYTICAL CHEMISTRY, 2000, 72 (14) :3158-3164
[2]  
ANTTILA A, UNPUB ADV MAT
[3]   Determination of cell viability in single or mixed samples using capillary electrophoresis laser-induced fluorescence microfluidic systems [J].
Armstrong, DW ;
He, LF .
ANALYTICAL CHEMISTRY, 2001, 73 (19) :4551-4557
[4]   A wireless electrochemiluminescence detector applied to direct and indirect detection for electrophoresis on a microfabricated glass device [J].
Arora, A ;
Eijkel, JCT ;
Morf, WE ;
Manz, A .
ANALYTICAL CHEMISTRY, 2001, 73 (14) :3282-3288
[5]   Micro total analysis systems. 2. Analytical standard operations and applications [J].
Auroux, PA ;
Iossifidis, D ;
Reyes, DR ;
Manz, A .
ANALYTICAL CHEMISTRY, 2002, 74 (12) :2637-2652
[6]  
Badal MY, 2002, J CHROMATOGR A, V947, P277
[7]  
Badman ER, 2000, J MASS SPECTROM, V35, P659, DOI 10.1002/1096-9888(200006)35:6<659::AID-JMS5>3.0.CO
[8]  
2-V
[9]   A miniature cylindrical quadrupole ion trap: Simulation and experiment [J].
Badman, ER ;
Johnson, RC ;
Plass, WR ;
Cooks, RG .
ANALYTICAL CHEMISTRY, 1998, 70 (23) :4896-4901
[10]   Separation of 100-kilobase DNA molecules in 10 seconds [J].
Bakajin, O ;
Duke, TAJ ;
Tegenfeldt, J ;
Chou, CF ;
Chan, SS ;
Austin, RH ;
Cox, EC .
ANALYTICAL CHEMISTRY, 2001, 73 (24) :6053-6056
12345678910