共 23 条
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode
被引:37
作者:
Angell, Richard M.
[1
]
Bamborough, Paul
[1
]
Cleasby, Anne
[1
]
Cockerill, Stuart G.
[1
]
Jones, Katherine L.
[1
]
Mooney, Christopher J.
[1
]
Somers, Donald O.
[1
]
Walker, Ann L.
[1
]
机构:
[1] GlaxoSmithKline R&D, Med Res Ctr, Stevenage SG1 2NY, Herts, England
关键词:
D O I:
10.1016/j.bmcl.2007.10.076
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compound is explained with reference to X-ray crystal structures. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:318 / 323
页数:6
相关论文