Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode

被引:37
作者
Angell, Richard M. [1 ]
Bamborough, Paul [1 ]
Cleasby, Anne [1 ]
Cockerill, Stuart G. [1 ]
Jones, Katherine L. [1 ]
Mooney, Christopher J. [1 ]
Somers, Donald O. [1 ]
Walker, Ann L. [1 ]
机构
[1] GlaxoSmithKline R&D, Med Res Ctr, Stevenage SG1 2NY, Herts, England
关键词
D O I
10.1016/j.bmcl.2007.10.076
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compound is explained with reference to X-ray crystal structures. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:318 / 323
页数:6
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