Desymmetrization by direct cross-metathesis producing hitherto unreachable P-stereogenic phosphine oxides

被引：21

作者：

Bisaro, F ^{[1
]}

Gouverneur, V ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

来源：

TETRAHEDRON | 2005年 / 61卷 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

cross-metathesis; desymmetrization; phosphine oxide;

D O I：

10.1016/j.tet.2005.01.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Desymmetrization of prochiral di- and trialkenyl phosphine oxides by cross-metathesis with various olefinic partners allowed direct access to novel racemic P-stereogenic products featuring two or three different alkenyl groups. The excellent control of product selectivity and E/Z selectivity allowed the preparation of desymmetrized products in good yields from readily available precursors. These are the first examples of desymmetrization of prochiral substrates by direct cross-metathesis. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2395 / 2400

页数：6

共 28 条

[1]

[Anonymous], 1972, ORGANIC PHOSPHORUS C

[2] Cross-metathesis, a versatile synthetic methodology for the construction of alkenyl phosphine oxides and bis-phosphine oxides [J].