Extracellular vesicles and redox modulation in aging

被引：35

作者：

Borras, Consuelo ^{[1
]}

Mas-Bargues, Cristina ^{[1
]}

Sanz-Ros, Jorge ^{[1
]}

Roman-Dominguez, Aurora ^{[1
]}

Gimeno-Mallench, Lucia ^{[1
]}

Ingles, Marta ^{[2
]}

Gambini, Juan ^{[1
]}

Vina, Jose ^{[1
]}

机构：

[1] Univ Valencia, Fac Med, Freshage Res Grp, CIBERFES,INCLIVA,Dept Physiol, Ave Blasco Ibanez 15, Valencia, Spain

[2] Univ Valencia, Fac Physiotherapy, Freshage Res Grp, CIBERFES,INCLIVA,Dept Physiotherapy, Ave Blasco Ibanez 15, Valencia, Spain

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2020年 / 149卷

基金：

欧盟地平线“2020”;

关键词：

Age-related disease; Extracellular vesicles; Treatment; Diagnosis; MESENCHYMAL STEM-CELLS; OXIDATIVE STRESS; MITOCHONDRIAL-DNA; EXOSOMES; MICROVESICLES; AGE; PROLIFERATION; ACTIVATION; LIPIDOMICS; CONTRIBUTE;

D O I：

10.1016/j.freeradbiomed.2019.11.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Extracellular vesicles (EVs) are nowadays known to be mediators of cell-to-cell communication involved in physiological and pathological processes. The current expectation is their use as specific biomarkers and therapeutic tools due to their inner characteristics. However, several investigations still need to be done before we can use them in the clinic. First, their categorization is still under debate, although an accurate classification of EVs subtypes should be based on physical characteristics, biochemical composition or condition description of the cell of origin. Second, EVs carry lipids, proteins and nucleic acids that can induce epigenetic modifications on target cells. These cargos, as well as EVs biogenesis, shedding and uptake is both ageing and redox sensitive. More specifically, senescence and oxidative stress increase EVs release, and their altered content can trigger antioxidant but also prooxidant responses in target cells thereby modulating the redox status. Further analysis would help to asses EVs role in the development and progression of oxidative stress-related pathologies. In this review we aimed to summarize the current knowledge on EVs and their involvement in redox modulation on age-related pathologies. We also discuss future directions and prospective that could be performed to improve EVs usage as biomarkers or therapeutic tools.

引用

页码：44 / 50

页数：7

共 53 条

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