Localized avidin/biotin derivatization of glassy carbon electrodes using SECM

被引:53
作者
Nowall, WB
Wipf, DO
Kuhr, WG [1 ]
机构
[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA
[2] Mississippi State Univ, Dept Chem, Mississippi State, MS 39762 USA
关键词
D O I
10.1021/ac971310b
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Different forms of the microreagent mode of SECM were used to attach biotin or make "clean" spots on micron-sized regions on the surface of a carbon electrode. In the direct-write mode, the SECM probe tip is used as an electrochemical "pen" depositing biotin in micron-sized lines on the carbon substrate as it is scanned across its surface. In the negative microreagent mode, the SECM probe tip is used as an electrochemical "eraser" cleaning off the surface attached molecules and leaving clean spots on the surface of a globally derivatized carbon surface. This type of simple micromodification of the surface of a carbon electrode will allow the fabrication of biosensors that can potentially be tailor-made for a variety of applications.
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页码:2601 / 2606
页数:6
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